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Index > Protein center > ANO1(Gene name) > Human
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  • ANO1 (Gene name),
  • Anoctamin-1 (Protein name ),  ANO1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ANO1(DOG1;ORAOV2;TAOS2;TMEM16A);
    Protein name:
    Anoctamin-1;
    Alternative:
    Oral cancer overexpressed protein 2;Discovered on gastrointestinal stromal tumors protein 1;Tumor-amplified and overexpressed sequence 2;Transmembrane protein 16A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acts as a calcium-activated chloride channel. Required for normal tracheal development.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cytoplasm
    Protein Attributes:
    Sequence length:
    986
    Sequence:
    50:
    MRVNEKYSTL | PAEDRSVHII | NICAIEDIGY | LPSEGTLLNS | LSVDPDAECK | 
    100:
    YGLYFRDGRR | KVDYILVYHH | KRPSGNRTLV | RRVQHSDTPS | GARSVKQDHP | 
    150:
    LPGKGASLDA | GSGEPPMDYH | EDDKRFRREE | YEGNLLEAGL | ELERDEDTKI | 
    200:
    HGVGFVKIHA | PWNVLCREAE | FLKLKMPTKK | MYHINETRGL | LKKINSVLQK | 
    250:
    ITDPIQPKVA | EHRPQTMKRL | SYPFSREKQH | LFDLSDKDSF | FDSKTRSTIV | 
    300:
    YEILKRTTCT | KAKYSMGITS | LLANGVYAAA | YPLHDGDYNG | ENVEFNDRKL | 
    350:
    LYEEWARYGV | FYKYQPIDLV | RKYFGEKIGL | YFAWLGVYTQ | MLIPASIVGI | 
    400:
    IVFLYGCATM | DENIPSMEMC | DQRHNITMCP | LCDKTCSYWK | MSSACATARA | 
    450:
    SHLFDNPATV | FFSVFMALWA | ATFMEHWKRK | QMRLNYRWDL | TGFEEEEEAV | 
    500:
    KDHPRAEYEA | RVLEKSLKKE | SRNKEKRRHI | PEESTNKWKQ | RVKTAMAGVK | 
    550:
    LTDKVKLTWR | DRFPAYLTNL | VSIIFMIAVT | FAIVLGVIIY | RISMAAALAM | 
    600:
    NSSPSVRSNI | RVTVTATAVI | INLVVIILLD | EVYGCIARWL | TKIEVPKTEK | 
    650:
    SFEERLIFKA | FLLKFVNSYT | PIFYVAFFKG | RFVGRPGDYV | YIFRSFRMEE | 
    700:
    CAPGGCLMEL | CIQLSIIMLG | KQLIQNNLFE | IGIPKMKKLI | RYLKLKQQSP | 
    750:
    PDHEECVKRK | QRYEVDYNLE | PFAGLTPEYM | EMIIQFGFVT | LFVASFPLAP | 
    800:
    LFALLNNIIE | IRLDAKKFVT | ELRRPVAVRA | KDIGIWYNIL | RGIGKLAVII | 
    850:
    NAFVISFTSD | FIPRLVYLYM | YSKNGTMHGF | VNHTLSSFNV | SDFQNGTAPN | 
    900:
    DPLDLGYEVQ | ICRYKDYREP | PWSENKYDIS | KDFWAVLAAR | LAFVIVFQNL | 
    950:
    VMFMSDFVDW | VIPDIPKDIS | QQIHKEKVLM | VELFMREEQD | KQQLLETWME | 
    986:
    KERQKDEPPC | NHHNTKACPD | SLGSPAPSHA | YHGGVL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    String:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human Anoctamin-1
    Cat.:
    E9186h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human Anoctamin-1
    Cat.:
    E9186m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Anoctamin-1
    Cat.:
    U9186h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Anoctamin-1
    Cat.:
    U9186m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Anoctamin-1
    Cat.:
    P9186Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Anoctamin-1
    Cat.:
    P9186Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Anoctamin-1
    Monoclonal Antibody for Human Anoctamin-1
    Protein for Human Anoctamin-1
    Protein for Human Anoctamin-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma."
      Huang X. , Godfrey T.E. , Gooding W.E. , McCarty K.S. Jr. , Gollin S.M.
      Genes Chromosomes Cancer45:1058-1069(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Testis.
      tissue: Uterus.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Testis.
    4. 4.
      "FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products."
      Katoh M. , Katoh M.
      Int. J. Oncol.22:1375-1381(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION;TOPOLOGY
    5. 5.
      "The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status."
      West R.B. , Corless C.L. , Chen X. , Rubin B.P. , Subramanian S. , Montgomery K. , Zhu S. , Ball C.A. , Nielsen T.O. , Patel R. , Goldblum J.R. , Brown P.O. , Heinrich M.C. , van de Rijn M.
      Am. J. Pathol.165:107-113(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    6. 6.
      "Head and neck squamous cell carcinoma transcriptome analysis by comprehensive validated differential display."
      Carles A. , Millon R. , Cromer A. , Ganguli G. , Lemaire F. , Young J. , Wasylyk C. , Muller D. , Schultz I. , Rabouel Y. , Dembele D. , Zhao C. , Marchal P. , Ducray C. , Bracco L. , Abecassis J. , Poch O. , Wasylyk B.
      Oncogene25:1821-1831(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "TMEM16A protein: a new identity for Ca(2+)-dependent Cl? channels."
      Ferrera L. , Caputo A. , Galietta L.J.
      Physiology (Bethesda)25:357-363(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    9. 9.
      "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"
      Duran C. , Hartzell H.C.
      Acta Pharmacol. Sin.32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "CFTR and TMEM16A are separate but functionally related Cl-channels."
      Ousingsawat J. , Kongsuphol P. , Schreiber R. , Kunzelmann K.
      Cell. Physiol. Biochem.28:715-724(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH CFTR;ENZYME REGULATION
    12. 12.
      "Characterization of the oligomeric structure of the Ca(2+)-activated Cl- channel Ano1/TMEM16A."
      Sheridan J.T. , Worthington E.N. , Yu K. , Gabriel S.E. , Hartzell H.C. , Tarran R.
      J. Biol. Chem.286:1381-1388(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    14. 14.
      "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
      Winpenny J.P. , Gray M.A.
      Exp. Physiol.97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    15. 15.
      "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."
      Scudieri P. , Sondo E. , Ferrera L. , Galietta L.J.
      Exp. Physiol.97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;FUNCTION;SUBCELLULAR LOCATION
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    17. 17.
      "Anoctamins are a family of Ca2+ activated Cl- channels."
      Tian Y. , Schreiber R. , Kunzelmann K.
      J. Cell Sci.125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
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